Our scientific interest is in the investigation of principles of molecular mechanisms in biological systems at the atomic level from the points of view of structural, molecular and computational biology.
Our major research areas are:
- study of endosomal immune response system with focus on interactions of proteases, their inhibitors and MHC class II molecules,
- study of mechanism amyloid fibril formation,
- development of computational tools of structural biology,
- development of links between nano-technology and moleclular biology
The molecules of our interest are proteases themselves, their substrates, including proenzymes, and inhibitors as regulators of their activity. In order to study the principles of intra- and intermolecular interactions the 3-dimensional structure of a macromolecule resolved to atomic details is an essential step.