Dušan Turk

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2016

Proceedings of the National Academy of Sciences of the United States of America

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The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins

Counter selection substrate library strategy for developing specific protease substrates and probes

2016

SAR and QSAR in environmental research

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Comparison of in silico tools for binding site prediction applied for structure-based design of autolysin inhibitors

Caught in the act : the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L

The mechanism behind the selection of two different cleavage sites in NAG-NAM polymers

2017

Trends in pharmacological sciences

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The future of cysteine cathepsins in disease management

The CWB2 cell wall-anchoring module is revealed by the crystal structures of the Clostridium difficile cell wall proteins Cwp8 and Cwp6

Protease cleavage site fingerprinting by label-free in-gel degradomics reveals pH-dependent specificity switch of legumain

2017

International journal of molecular sciences

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Proline residues as switches in conformational changes leading to amyloid fibril formation

Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin

Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families

2017

Protein crystallography : methods and protocols

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Boxes of model building and visualization

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes

2018

Journal of enzyme inhibition and medicinal chemistry

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Discovery of (phenylureido)piperidinyl benzamides as prospective inhibitors of bacterial autolysin E from Staphylococcus aureus

2018

SAR and QSAR in environmental research

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Application of fragment based virtual screening towards inhibition of bacterial N-acetyglucosaminidase

A water-assisted catalytic mechanism in glycoside hydrolases demonstrated on the Staphylococcus aureus autolysin E

Validation and quality assessment of macromolecular structures using complex network analysis

2019

Journal of the American Chemical Society : JACS

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The alkyne moiety as a latent electrophile in irreversible covalent small molecule inhibitors of cathepsin K

2019

Acta chimica slovenica

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Characterization of legumain degradome confirms narrow cleavage specificity

2019

Acta chimica slovenica

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Characteristics, structure, and biological role of stefins (type-1 cystatins) of human, mammal, and parasite origin

2020

Nature : the international weekly journal of science

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The structure of human thyroglobulin

2020

International journal of molecular sciences

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The structure of clostridioides difficile SecA2 atpase exposes regions responsible for differential target recognition of the SecA1 and SecA2-dependent systems

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

2021

Acta crystallographica. Section D, Structural biology.

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Thyroxine hormones visualized by the cryo-EM structure of bovine thyroglobulin

Time-resolved crystallography captures light-driven DNA repair

2023

Communications biology

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Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins

2023

Communications biology

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Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections

2024

Journal of medicinal chemistry

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Structural elucidation and antiviral activity of covalent cathepsin L inhibitors

2024

Frontiers in cellular and infection microbiology

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Modulation of Campylobacter jejuni adhesion to biotic model surfaces by fungal lectins and protease inhibitors

2024

Microbial biotechnology

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Exposure to specific fungal lectins during adhesionimpairs biofilm formation of Listeria on polystyrene

2024

Carbohydrate polymers

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Antigenic determinants driving serogroup-specific antibody response to Neisseria meningitidis C, W, and Y capsular polysaccharides : insights for rational vaccine design

2025

International journal of molecular sciences

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Structural and proteomic analysis of the mouse cathepsin B-DARPin 4m3 complex reveals species-specific binding determinants

2025

International journal of biological macromolecules

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Fungal lectins show differential antiproliferative activity against cancer cell lines

Development and application of small molecule-peptide conjugates as cathepsin K-specific covalent irreversible inhibitors in human osteoclast and lung cancer

2026

Journal of agricultural and food chemistry

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The Entomotoxic fungal lectin Marasmius oreades agglutinin disrupts the midgut epithelium of Colorado potato beetle larvae

2020

International journal of molecular sciences

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

The structure of clostridioides difficile SecA2 atpase exposes regions responsible for differential target recognition of the SecA1 and SecA2-dependent systems

2020

Communications biology

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

Domain sliding of two Staphylococcus aureus N-acetylglucosaminidases enables their substrate-binding prior to its catalysis

2020

Applied and environmental microbiology

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Insights into the maturation of pernisine, a subtilisin-like protease from the hyperthermophilic archaeon Aeropyrum pernix

2021

International journal of molecular sciences

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Mechanisms applied by protein inhibitors to inhibit cysteine proteases

A mini-TGA protein modulates gene expression through heterogeneous association with transcription factors

2022

International journal of molecular sciences

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Cocaprins, β-trefoil fold inhibitors of cysteine and aspartic proteases from coprinopsis cinerea

2022

Communications biology

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Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease

2021

Biochimica et biophysica acta. Proteins and proteomics.

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Dušan Turk

dusan.turk@ijs.si

Publications by

Dušan Turk

The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins

Counter selection substrate library strategy for developing specific protease substrates and probes

Comparison of in silico tools for binding site prediction applied for structure-based design of autolysin inhibitors

Caught in the act : the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L

The mechanism behind the selection of two different cleavage sites in NAG-NAM polymers

The future of cysteine cathepsins in disease management

The CWB2 cell wall-anchoring module is revealed by the crystal structures of the Clostridium difficile cell wall proteins Cwp8 and Cwp6

Protease cleavage site fingerprinting by label-free in-gel degradomics reveals pH-dependent specificity switch of legumain

Proline residues as switches in conformational changes leading to amyloid fibril formation

Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin

Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families

Boxes of model building and visualization

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes

Discovery of (phenylureido)piperidinyl benzamides as prospective inhibitors of bacterial autolysin E from Staphylococcus aureus

Application of fragment based virtual screening towards inhibition of bacterial N-acetyglucosaminidase

A water-assisted catalytic mechanism in glycoside hydrolases demonstrated on the Staphylococcus aureus autolysin E

Validation and quality assessment of macromolecular structures using complex network analysis

The alkyne moiety as a latent electrophile in irreversible covalent small molecule inhibitors of cathepsin K

Characterization of legumain degradome confirms narrow cleavage specificity

Characteristics, structure, and biological role of stefins (type-1 cystatins) of human, mammal, and parasite origin

The structure of human thyroglobulin

The structure of clostridioides difficile SecA2 atpase exposes regions responsible for differential target recognition of the SecA1 and SecA2-dependent systems

X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease

Thyroxine hormones visualized by the cryo-EM structure of bovine thyroglobulin

Time-resolved crystallography captures light-driven DNA repair

Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins

Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections

Structural elucidation and antiviral activity of covalent cathepsin L inhibitors

Modulation of Campylobacter jejuni adhesion to biotic model surfaces by fungal lectins and protease inhibitors

Exposure to specific fungal lectins during adhesionimpairs biofilm formation of Listeria on polystyrene

Antigenic determinants driving serogroup-specific antibody response to Neisseria meningitidis C, W, and Y capsular polysaccharides : insights for rational vaccine design

Structural and proteomic analysis of the mouse cathepsin B-DARPin 4m3 complex reveals species-specific binding determinants

Fungal lectins show differential antiproliferative activity against cancer cell lines

Development and application of small molecule-peptide conjugates as cathepsin K-specific covalent irreversible inhibitors in human osteoclast and lung cancer

The Entomotoxic fungal lectin Marasmius oreades agglutinin disrupts the midgut epithelium of Colorado potato beetle larvae

The structure of clostridioides difficile SecA2 atpase exposes regions responsible for differential target recognition of the SecA1 and SecA2-dependent systems

Domain sliding of two Staphylococcus aureus N-acetylglucosaminidases enables their substrate-binding prior to its catalysis

Insights into the maturation of pernisine, a subtilisin-like protease from the hyperthermophilic archaeon Aeropyrum pernix

Mechanisms applied by protein inhibitors to inhibit cysteine proteases

A mini-TGA protein modulates gene expression through heterogeneous association with transcription factors

Cocaprins, β-trefoil fold inhibitors of cysteine and aspartic proteases from coprinopsis cinerea

Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease

Human cathepsin X/Z is a biologically active homodimer.