Proteolysis and its regulation in health and disease

Proteolytic processing is one of the most important irreversible posttranslational protein modifications, since it affects a great variety of physiological processes critical for life, including the immune response, cell cycle, cell death, and protein and organelle recycling. Proteases are strictly controlled and imbalances in their activities have been found to be critical in a number […]

Structural biology

The proposed “Structural biology” program follows the premise that physiological processes can be reproduced in vitro once we know all molecular components and understand their properties and interactions. Such understanding requires insight in the molecular mechanisms from the points of view of structural, molecular, and computational biology. It is the atomic 3-dimensional structures of macromolecules […]

Research paper “Cathephisn L mediated EGFR cleavage affects intracellular signalling pathways in cancer” accepted for publication in Biological Chemistry

Our coworkers Marija Grozdanić, Barbara Sobotič (joint first authorship), Monika Biasizzo, Tilen Sever, Robert Vidmar, Matej Vizovišek, Boris Turk and Marko Fonović have successfully submitted a research paper titled “Cathephisn L mediated EGFR cleavage affects intracellular signalling pathways in cancer” in the journal Biological Chemistry. In the study, the authors confirmed EGFR as a cathepsin […]

Lecture: Modulation of the stability of cystatin C by intra- and extramolecular factors

Prof. Aneta Szymańsk Department of Biomedicinal Chemistry, Faculty of Chemistry, University of Gdańsk, Poland 28. 9. 2023 – 10:15 – B220 Human cystatin C (hCC) is associated with physiological and pathological processes in human organism. It functions mainly as an inhibitor of cysteine proteases, but also exhibits neurodegenerative and neuroprotective properties. The wild-type protein modulates […]

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