Research Paper on Cathepsin L-Mediated EGFR Cleavage Published in Biological Chemistry

Research Paper on Cathepsin L-Mediated EGFR Cleavage Published in Biological Chemistry

Authors:

Marija Grozdanić, Barbara Sobotič (joint first authorship), Monika Biasizzo, Tilen Sever, Robert Vidmar, Matej Vizovišek, Boris Turk, Marko Fonović

Overview:

Our coworkers, led by Marija Grozdanić and Barbara Sobotič, have successfully submitted and had their research paper titled “Cathepsin L-Mediated EGFR Cleavage Affects Intracellular Signalling Pathways in Cancer” accepted for publication in the prestigious journal Biological Chemistry.

Key Findings:

• EGFR as Cathepsin L Substrate: The study confirmed that EGFR is a substrate of Cathepsin L.
• Cleavage Site Identified: The research identified the cleavage site on the extracellular domain of the receptor.
• Impact on Cancer: The modification leads to altered EGFR signalling, which is linked to cancer progression and resistance to EGFR inhibitor drugs.

Implications:

Understanding the changed EGFR functionality due to Cathepsin L-mediated cleavage offers crucial insights into the mechanism of cancer cell resistance to EGFR-targeted therapies. This knowledge could aid in the development of more effective cancer treatments.

Read the Full Article:

https://doi.org/10.1515/hsz-2023-0213