- Cathepsins B and X in breast cancer stem cells – molecular targets and relevance for antitumor therapy
- Aptamers and hydrodynamic cavitation, an accessible tool for the analysis of organic residuals in archaeological pottery
- Systemic determination of legumain physiological rolesLegumain is an evolutionary conserved cysteine protease with narrow substrate specificity. It is ubiquitously expressed in various cell and tissue types of animals, plants and other eukaryotes. Although it is … Read more
- Dissecting cancer activome to develop new generation of antibody-drug conjugates
- Human Cathepsin F: An unusual cysteine protease involved in neurodegenerationLysosomal cysteine cathepsins play key roles in various physiological and pathological processes, including aging, neurodegeneration and genetic diseases. Their disregulated activities result in numerous human diseases and consequently are promising … Read more
- Structural insight into the mechanism of Clostridium difficile surface formationThe cell wall of Gram-positive bacteria is composed of proteins and peptidoglycan with the protruding secondary polysaccharides, which differ in the chemical composition and structure among various species. The cell … Read more
- Proteolysis and its regulation in health and diseaseProteolytic processing is one of the most important irreversible posttranslational protein modifications, since it affects a great variety of physiological processes critical for life, including the immune response, cell cycle, … Read more
- Structural biologyThe proposed “Structural biology” program follows the premise that physiological processes can be reproduced in vitro once we know all molecular components and understand their properties and interactions. Such understanding … Read more
- Cathepsin-based non-invasive diagnostics of cancer
- Role of cysteine cathepsins in complement activation in cancerThere is still a significant unmet need for successful early diagnosis and treatment of major life-threatening or debilitating diseases like cancer and other inflammation-associated diseases, making this project of high … Read more