Financed by the Slovenian Research Agency
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Proteolysis and its regulation in health and disease
Proteolytic processing is one of the most important irreversible posttranslational protein modifications, since it affects a great variety of physiological processes critical for life, including the immune response, cell cycle, cell death, and protein and organelle recycling. Proteases are strictly controlled and imbalances in their activities have been found to be critical in a number…
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Structural biology
The proposed “Structural biology” program follows the premise that physiological processes can be reproduced in vitro once we know all molecular components and understand their properties and interactions. Such understanding requires insight in the molecular mechanisms from the points of view of structural, molecular, and computational biology. It is the atomic 3-dimensional structures of macromolecules…