My main research interests are method development for determination of protease cleavage sites and protease cleavage specificity, discovery of novel protease physiological substrates and implementation & development of bioinformatics tools for proteomics protease research. At the Department of Biochemistry, Molecular and structural biology I work at the Proteomics lab, where I cover all aspects of work from sample preparation to data analysis.
Postdoctoral Researcher Jozef Stefan Institute
- 2016 –
Assistant Researcher Jozef Stefan Institute
- 2010 – 2016
Student Researcher Lek (Biopharmaceuticals Sandoz, Novartis)
- 2008 – 2010 (with breaks)
2010 – 2016
PHD Biochemistry, Jozef Stefan International Postgraduate School
Title: Proteomic characterization of legumain and its physiological substrates (mentor: prof. dr. Marko Fonović). Experimental work was performed at the Department of Biochemistry, Molecular and structural biology, Jozef Stefan Institute
2004 – 2010
University graduate in Biochemistry, B. Sc., Faculty of Chemistry and Chemical Biology, University of Ljubljana
Title: Peptide map development for identity testing of therapeutic protein (co-mentor: dr. Igor Štern, mentor: prof. dr. Lucija Zupančič-Kralj. Experimental work was performed at Lek (Biopharmaceuticals Sandoz, Novartis).
Vidmar Robert, Vizovisek Matej; Turk Dušan; Turk Boris; Fonović Marko. Protease cleavage site fingerprinting by label-free in-gel degradomics reveals pH-dependent specificity switch of legumain. EMBO journal. 2017, vol. 36, no. 16, 2455-2465.
Vizovišek Matej; Vidmar Robert; Drag Marcin; Fonović Marko, Salvesen Guy Salvesen, Turk Boris. Protease Specificity: Towards In Vivo Imaging Applications and Biomarker Discovery. Trends Biochem Sci. 2018, vol. 10, 829-844.
Vidmar Robert; Vizovisek Matej; Turk Dušan; Turk Boris; Fonović Marko. Characterization of legumain degradome confirms narrow cleavage specificity. Acta chimica slovenica. 2019, vol. 66, no. 1, 50-57
Sobotič Barbara; Vizovisek Matej; Vidmar Robert; Van Damme Petra; Gocheva Vasilena; Joyce Johanna; Gevaert Kris; Turk Vito; Turk Boris; Fonović, Marko. Proteomic identification of cysteine cathepsin substrates shed from the surface of cancer cell. Molecular & Cellular Proteomics, 2015, vol. 14, no. 8, p. 2213-2228.
Vizovišek Matej; Vidmar Robert; Van Quickelberghe Emmy; Impens Francis; Andjelkovic Uroš; Sobotič Barbara; Stoka Veronika; Gevaert Kris; Turk Boris; Fonović Marko. Fast profiling of protease specificity reveals similar substrate specificities for cathepsins K, L and S. Proteomics, 2015, vol. 15, issue 14, p. 2479-2490.