Our coworkers Marija Grozdanić, Barbara Sobotič (joint first authorship), Monika Biasizzo, Tilen Sever, Robert Vidmar, Matej Vizovišek, Boris Turk and Marko Fonović have successfully submitted a research paper titled “Cathephisn L mediated EGFR cleavage affects intracellular signalling pathways in cancer” in the journal Biological Chemistry. In the study, the authors confirmed EGFR as a cathepsin L substrate and determined the cleavage site on the extracellular domain of the receptor. The modification leads to changes in EGFR signalling present in several types of cancer. Understanding the changed EGFR functionality will help us understand the mechanism of cancer cell resistance to EGFR inhibitor drugs.