Article in Cells: Cystatin C Deficiency Increases LPS-Induced Sepsis and NLRP3 Inflammasome Activation in Mice

In collaboration with the colleagues from the Faculty of Medicine and Faculty of Chemistry and Chemical Technology, University of Ljubljana, we published a paper entitled: Cystatin C Deficiency Increases LPS-Induced Sepsis and NLRP3 Inflammasome Activation in Mice (Cells2021, 10(8), 2071; https://doi.org/10.3390/cells10082071) Abstract Cystatin C is a potent cysteine protease inhibitor that plays an important role […]

Open PhD Position

2 full-time PhD positions are open at the Department of Biochemistry, Molecular and Structural Biology at Jožef Stefan Institute, starting on October 1, 2021. We are looking for a highly motivated and enthusiastic candidate with master’s degree in biochemistry or closely related field. Application and additional information: georgy.mikhaylov@ijs.si and veronika.stoka@ijs.si.

Human Cathepsin F: An unusual cysteine protease involved in neurodegeneration

Lysosomal cysteine cathepsins play key roles in various physiological and pathological processes, including aging, neurodegeneration and genetic diseases. Their disregulated activities result in numerous human diseases and consequently are promising drug targets. Among eleven human cysteine cathepsins, cathepsin F is one of the less studied and characterized proteases. The recent discovery of several mutations within […]

Scroll to top