Systemic determination of legumain physiological roles

Legumain is an evolutionary conserved cysteine protease with narrow substrate specificity. It is ubiquitously expressed in various cell and tissue types of animals, plants and other eukaryotes. Although it is primarily located in the endo/lysosomal compartments, legumain can be translocated to the cytosol, nucleus and extracellular space. In the last decade, numerous studies have connected […]

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